Harvard and Brigham and Women’s Hospital researchers have devised a method that may allow clinicians to use higher doses of a powerful chemotherapy drug that has been limited because it is toxic not only to tumors but to patients’ kidneys.The research, conducted in laboratory animals, marries chemistry and nanotechnology to deliver toxic platinum atoms to tumors while almost entirely blocking the platinum from accumulating in the kidney, according to Shiladitya Sengupta, a Harvard assistant professor of medicine and health sciences and technology whose Laboratory for Nanomedicine at Harvard-affiliated Brigham and Women’s Hospital conducted the work.Sengupta has focused his research for three years on cisplatin, a powerful anti-cancer drug used in first-line chemotherapy. Sengupta said the drug, discovered about 40 years ago, has many positive aspects. It is relatively inexpensive and effective against many cancers. Its toxicity, however, limits its use.“Even if you can see amazing results as an anti-tumor therapy, you can’t give more,” Sengupta said.Despite several attempts, cisplatin hasn’t been improved upon, Sengupta said. Two similar drugs that also incorporate platinum are on the market, but while they are less toxic to the kidney, they are also less active against tumors.Though the chemistry involved is complex, the key to cisplatin’s effectiveness — and its toxicity — lies in how easily it releases platinum, both at the tumor site and, undesirably, in the kidneys.Manufacturers of the two alternative drugs have reduced those drugs’ toxicity by making them hold onto their platinum more tightly. Sengupta’s work took a different track, however. Understanding that particles greater than five nanometers in size would not be absorbed by the kidney, he set out to engineer a super-sized cisplatin.Understanding the chemical properties of the cisplatin molecule and the laws that govern molecular folding, his team designed a polymer that would bind to cisplatin, much as a thread runs through a bead’s central hole. By stringing together enough cisplatin, the whole molecule wrapped itself into a ball, 100 nanometers in size, too large to enter the kidney.It took a couple of tries to get the molecular design right, Sengupta said. Though the initial design proved nontoxic to kidneys, it wasn’t as effective as the original cisplatin. Sengupta and colleagues tweaked the chemical formula so the molecule didn’t hold quite so tightly to the platinum atoms.Studies conducted by Basar Bilgicer, assistant professor at the University of Notre Dame, showed that the molecule accumulated in tumor tissue, whose leaky blood vessels allowed it to pass out of the capillaries that feed the tumor. The molecule is too large to pass into other tissues, such as the kidney, lungs, liver, and spleen. Once lodged in the tumor, the higher acidity there caused the molecule to fall apart, dumping its toxic load on the cancerous tissue.“It showed absolutely minimal toxicity to the kidney,” Sengupta said.The new compound has been found to be effective against lung and breast cancers. Instructor in pathology Daniela Dinulescu at Brigham and Women’s Hospital also demonstrated that the nano-compound outperformed cisplatin in a transgenic ovarian cancer model that mimics the disease in humans.The research, which received funding from the National Institutes of Health and the Defense Department’s Breast Cancer Research Program, has not been tried in humans, and would require potentially lengthy testing before being ready for patient care.Described in this week’s Proceedings of the National Academy of Sciences, the project also included researchers at the University of Notre Dame, the Harvard-MIT Division of Health Sciences and Technology, the Dana-Farber Cancer Institute, the National Chemical Laboratory in Pune, India, and the Translational Health Science and Technology Institute in New Delhi.Sengupta praised the work and creativity of fellows Abhimanyu Paraskar and Shivani Soni on the project.
Gasps echoed through the Radcliffe gymnasium on Wednesday as audience members reacted to the image of a woman’s foot, projected on a large screen at the front of the hall.It was a foot in name only. The misshapen mass looked more like a hoof bisected by a crack. The deformity was the result of foot binding, a common practice in much of China until the middle of the last century that involved wrapping the foot of a young girl or woman tightly with a cloth to stunt its growth, explained Laurel Bossen, the Carl and Lily Pforzheimer Foundation Fellow at the Radcliffe Institute for Advanced Study.That particular type of bound foot was called “the three-inch golden lotus,” said Bossen. “That’s the ideal. It gradually broke the girl’s arch … you can see that the arch is just a crevasse on that foot.”While at Harvard, Bossen and Melissa Brown, Radcliffe’s Frieda L. Miller Fellow, in collaboration with anthropologist Hill Gates, are writing a book on female labor and foot binding in early 20th century China. Their research is based in part on large-scale surveys in the 1990s done by Gates, and on their own interviews from the past few years with thousands of elderly women from 11 provinces in rural China.Their findings dispel several “origin myths” and mistaken assumptions associated with the brutal custom.The scholars reject the prevailing theories that bound feet in China were considered more beautiful, a means of male control over women, a sign of class status, and a chance for women to marry well. They also reject the widespread notion that such women couldn’t work, and thus contributed little to their families and the larger economy, and the belief that campaigns against the practice were what ultimately put an end to it.Instead, their research suggests that the practice was directly linked to the use of young girls and women in the hand-labor force, and that its disappearance coincided with the arrival in China of the Industrial Revolution.When they asked women during interviews why they thought their feet were bound, many responded that they were expected to “marry up economically,” said Brown, a researcher at the Minnesota Population Center at the University of Minnesota who is interested in historical processes of transformative social and cultural change.But she questioned the notion that bound feet were considered more alluring to men and that they could lead to a better marriage, because men weren’t picking their own brides. Their mothers were.“Why in the world would a mother want to pick a sexy daughter-in-law?”While the women surveyed thought foot binding would lead to a good marriage, the numbers didn’t add up. After a detailed analysis, the researchers found no overall statistically significant data to support the theory that women with bound feet were in more prosperous households after marriage as compared with their birth households.“What we found, in fact, is that there is not a link,” said Brown, adding, “The majority show no marital mobility.”So why were the feet of 7-year-old girls bound so often if the end result had no impact on their ability to marry above their class?The answer involves a financial reality.“For me, the question about foot binding has always been ‘How could rural families afford to lose women’s labor’ ”? said Bossen, anthropology professor emerita at McGill University. “What work could they do when they had bound feet?”Bossen said the research points to a clear connection between foot binding and hand labor. Mothers needed their daughters’ help to produce both cloth for the family and extra cloth for sale. They needed to keep their “willful, playful” young daughters at their sides, she said, to have them learn how to spin, wind, twist, and weave fibers they could sell when the crops failed or fell short at harvest.“For girls who are doing handwork for income, the odds are 4.5 to 1 that they will be bound,” said Bossen of the studies they conducted in China’s Yunnan Province.“Foot binding can be seen as a way of tying them down, and training them in the handwork, supervising them, and keeping them close at hand. It’s not the only way, but I would argue it became part of the cultural repertory.”And as the value of women’s hand labor decreased, so did foot binding.The eventual arrival of the Industrial Revolution had a dramatic impact on women’s work, as cotton yarn began to be imported and factories eventually replaced the work women did by hand. Citing research that spanned the 1920s to the 1940s, the researchers found that the likelihood that a woman doing commercial handwork would also have bound feet dropped drastically.The link between commercial handwork and foot binding is “highly statistically significant,” said Bossen. The arrival of cheaper machines made textiles “undercut income from hand labor and caused foot binding rates to plummet.”
Sign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York Republican Tom Croci defeated Tuesday his Democratic challenger Adrienne Esposito for a New York State Senate seat that was once thought to be a toss up before Croci replaced his party’s original nominee over the summer amid a toxic dumping scandal that shook up the race.Croci, the 42-year-old freshman Islip Town Supervisor who jumped into the race late, beat Esposito, 53, the executive director of nonprofit Citizens Campaign for the Environment, 58 to 41 percent, according to unofficial results from the Suffolk County Board of Elections.“I could not be prouder than to be standing here with my former boss and the next congressman from Long Island, Lee Zeldin,” Croci said from the stage at The Emporium in Patchog where Suffolk County Republicans held their election night party. “I will work twice as hard because of the shoes I’ll have to fill.”He will take over the seat left vacant by state Sen. Lee Zeldin (R-Shirley), who gave up his seat for a hotly-contested race against U.S. Rep. Tim Bishop (D-Southampton), whom Zeldin unseated. Croci also gave a nod to Caesar Trunzo, who previously held the same state Senate seat.Croci, a U.S. Navy reservist, was deployed overseas when the dumping scandal erupted. He returned to Long Island in July and announced he’d run for the seat after Anthony Senft, a Conservative Islip Town Councilman and liaison to the town’s park department, dropped out soon after it became public that someone was dumping carcinogen-laced debris in a town park and other areas.Croci was said to have a large lead in pre-Election Day polls, and his victory came as no shock.This was Esposito’s first run for elected office, who was also vying to become the first female state Senator in Suffolk County history.. As a longtime environmental advocate, she has spent years pushing for reforms and legislation to protect LI from polluters. But she was no match for Croci, who unseated the Democratic incumbent Phil Nolan in a close race for Islip Town Supervisor in 2011.Esposito had trouble appealing to voters and lacked Croci’s name recognition, according to two Newsday/ News 12 Long Island/Siena College polls conducted in October.Croci was mostly able to sidestep criticism regarding the dumping scandal. Upon his return to the Island in July, he apologized to residents and promised to clean up the mess. His campaign was focused on job creation, controlling taxes, opposing Common Core, a tough stance on crime and environmental protection.There were few surprises in the other eight LI state Senate races, with Sen. Dean Skelos (R-Rockville Centre) recapturing a majority in the upper chamber of the state Legislature upon his re-election. All the local incumbents were re-elected as well and Nassau County Legis. Michael Venditto (R-Massapequa) won the seat vacated by ex-Sen. Charles Fuschillo (R-Merrick).
A meeting was held at the Ministry of Tourism on the topic of a 12-month moratorium on leasing without charging interest, with the participation of the Voice of Entrepreneurs Association (UGP), the Occasional Passenger Transport Initiative (PPP), the Ministry of the Sea, Transport and Infrastructure and representatives of seven leasing companies, I believe that a big step forward has been made with the positive responses of leasing companies, but the work is not even close, said Marko Slišković from the PPP Initiative and added: “Očekujem nakon dostave dokumenata koji su zatraženi od nas i leasing kuća da država promptno reagira na način kako je i obećano, kako bismo već sljedeći tjedan bili sigurni da je spašeno više od 2000 tvrtki s 20 000 zaposlenika. Također, potrebno i da druge leasing kuće prihvate dogovor, pogotovo Mercedes Benz leasing koji do sada nije pokazao nimalo razumijevanja za svoje klijente. ” said Slišković, adding that this problem can only be resolved in tripartite. UGP and IPPP prepared a joint document with which other employers’ associations agreed. It contains proposals to the Government on how to resolve this situation. Leasing a house will do the same. UGP and the Occasional Passenger Transport Initiative (PPP) have repeatedly warned that leasing companies in Croatia have not responded adequately to the new situation caused by the coronavirus pandemic, and their actions jeopardize the survival of the entire tourist branch of occasional passenger transport. Kako ističu iz UGP-a, prisutne leasing kuće složile su se s prijedlozima UGP-a i Inicijative povremenog prijevoza putnika.” The present leasing companies undertook to offer a deferral of principal and interest for 12 months as a matter of urgency, and the only open question was the method of calculating and writing off interest.” “I am extremely sorry that we did not agree on such a solution at the first meeting we had at HANFA almost a month ago, because this time it is the only way we can all overcome the crisis with minimal job losses. I expect a quick reaction from the Ministry of Finance and their concrete proposal based on our documents. A tripartite agreement between the users, leasing companies and the Government is the only correct way to the solution. ” He said Dražen Oreščanin, executive director of the association Glas Poduzetnika. The PPP and UGP initiative proposed the following: Calculation of interest in such a way that in the period of deferral, monthly interest is calculated on the deferred monthly principal in the amount agreed in the Leasing Agreement. Through HBOR, the government should provide funds to leasing companies at more favorable interest rates than before. It is necessary to establish a guarantee fund whose source would be within the non-refundable 7,3 billion euros that will be available to Croatia from the European Union. In this case, after the moratorium expires in March or April next year, when these funds will be available, leasing companies would write off interest to their clients, while the state would pay leasing companies half of the accrued interest under the current model, and the other half would be leasing. houses was recognized as a tax deduction. Nakon mnogo akcija UGP-a i Inicijative PPP te niza prosvjeda, uključujući onaj prvi poduzetnika, ministarstva su napokon odlučila reagirati i uključiti se u rješavanje problema povremenog prijevoza, ističu iz UGP-a te dodaju: “Representatives of the Ministry of Finance did not attend the meeting, which we consider extremely bad because they are the key to solving the problem, as well as representatives of Mercedes Benz leasing, Agram and PBZ leasing, whose clients are many of our members. We consider this a marked disrespect for the Croatian state and their clients.”Point out from UGP.
BLOG: Governor Wolf Rejects GOP Budget That Cuts Education (ROUND-UP) SHARE Email Facebook Twitter December 30, 2015 Budget News, Round-Up, The Blog Yesterday, Governor Tom Wolf rejected the Republican budget that cuts $95 million from education and is out-of-balance, while directing emergency funding for key services. Last week, Republican leaders walked away from a historic bipartisan budget agreement and passed an irresponsible budget so they could return home to their districts and take holiday vacations.Check out what editorial pages had to say:Philadelphia Inquirer: Editorial Board: Toying with state budget“Legislators who say they are being fiscally responsible are proposing budget gimmicks such as not paying bills on time, which would deepen the deficit. Anyone with basic arithmetic skills can figure out the truth. That includes Wall Street, which by lowering the state’s credit rating has increased the state’s debt service costs.” [Philadelphia Inquirer, 12/30/15]Philadelphia Daily News: Editorial Board: BUDGET MAKES NO $EN$E“To begin with, the budget the Republican Legislature passed last week and left on the governor’s desk was as phony as a three-dollar bill. The $30.3 billion budget pretended to be balanced, but it was not. It exceeded available revenue by $300 million. It pretended to fund all vital state services, but it did not. The Legislature sort of forgot to include $550 million in state support for Temple, Pitt and Penn State. The budget pretended to increase state funding for education, but it did not. It added more money to the basic education subsidy, while taking away a $304 million item to help school district’s pay construction and repair bills. The net result is that the state’s districts would get a cut in state aid.” [Philadelphia Daily News, 12/30/15]Times-Tribune: Editorial Board: Unbalanced, unacceptable“The bill does not move the state government or the state itself forward by even an inch. It leaves unresolved the most pressing needs facing the government and the people it is supposed to serve: adequate education funding, property tax reform, public pension reform, economic development and job creation. It will not methodically eliminate a structural state deficit. It will not reverse the credit downgrades that rating agencies have placed on many school districts statewide. And it will not cover the more than $900 million that districts already have had to borrow to stay in business.” [Times-Tribune, 12/30/15]Public Opinion: An unfinished, unbalanced state budget“We refer to the institutions like Moody’s and Standard & Poor’s that set the state’s credit ratings. Multiple agencies have downgraded the state’s borrowing ability due to the budget impasse and revenue gimmicks that don’t add up…..Until we get a serious explanation and solution from the GOP, absent the rhetoric and one that we can all understand, we have to conclude that lawmakers are prioritizing party politics over the state’s future.” [Public Opinion, 12/30/15] By: Beth Melena, Directer of Operations Like Governor Tom Wolf on Facebook: Facebook.com/GovernorWolfWatch Governor Wolf’s remarks on rejecting the Republican plan to cut education (and read the transcript of the remarks).
The draft programme, leaked to national media outlets last week, categorised pensions as one of several “long-term challenges” facing the country the administration should seek to address.The programme said the Irish political system remained “too focused on the short term” and failed to accommodate long-term thinking on policy areas including housing, long-term funding of health and education, and pension policy.It is possible further detail of any pension reform could be contained in ministerial strategy statements, which the programme pledges each department will draft, consulting on its contents with stakeholders and fellow lawmakers.Despite Fine Gael’s reliance on a grouping of independent parliamentarians to form a minority government, discussions on the rollout of a universal second-pillar pension system may still succeed.The main opposition party, Fianna Fáil, has agreed to support Kenny’s administration on budget matters, and both Fianna Fáil and Fine Gael pledged to introduce an auto-enrolment-based supplementary pension system in their manifestos ahead of February’s inconclusive election.Preliminary work on the reform began more than a year ago, when the previous government launched the Universal Retirement Savings Group (URSG) to advise on the design of a new occupational pension system.The Irish Pensions Authority has separately pledged to publish a document on pension reform by the summer, outlining how the sector could be regulated in future. Housing and sovereign wealthThe draft programme for government also said the country’s sovereign development fund, the Ireland Strategic Investment Fund (ISIF), would be one of the partners in a new scheme to boost private sector housing construction, working alongside the European Investment Bank and the Central Bank of Ireland to draft the new ‘Help to Build’ programme within the government’s first year.It added: “We will support the Irish Strategic Investment Fund [sic] to encourage the delivery of housing-related enabling infrastructure in large-scale priority development areas.”The ISIF has already backed a €500m residential housing venture with KKR, which it hopes will see the development of more than 11,000 new homes. Ireland’s new government has pledged to continue work on a universal second-pillar pension system despite the Fine Gael-led administration’s lack of a majority in Parliament.Enda Kenny, who won support last week for a second term as Taoiseach, or prime minister, following an inconclusive general election in February, has named Leo Varadkar minister for social protection, succeeding Joan Burton after five years in the role.Varadkar, a former transport and health minister, told public broadcaster RTÉ on 7 May the introduction of a universal pension system would be one of his priorities while at the Department of Social Protection.The pledge comes despite the briefest of mentions of pension reform in a draft government programme, outlining the legislative programme of the Fine Gael-led minority government.
Alpha Petroleum Resources, an upstream oil and gas operator focused on the UK sector of the North Sea, has appointed Charles Proctor, a former executive at BP and Genel Energy, as its new chief financial officer.Proctor has over 28 years of experience in the international energy industry having held senior executive positions at major corporations and worked with smaller, more entrepreneurial businesses.In his early career, he held several commercial and financial roles in BP’s businesses in the UK, internationally, and in the company’s corporate headquarters. He subsequently became CFO for BP’s major exploration and production businesses in Angola and later Azerbaijan. In 2009, he was appointed the head of the BP Group chief executive’s office and became Regional President for BP Middle East in 2010.In 2012, Proctor left BP to join the executive team of Genel Energy, an independent exploration and production company established in 2011 as Head of Commercial and regional president for Africa. Since 2015, he has been working as an industry consultant providing advisory services to several existing and start-up energy companies and is also an independent member of the supervisory board of Naftogaz of Ukraine.Andy Crouch, Alpha Petroleum’s CEO, said: “His [Proctor’s] considerable international experience at an executive level will greatly add to the team’s existing expertise. To welcome such a veteran of the sector who also understands the challenges that face a smaller entrepreneurial business such as ours will be invaluable as we continue to develop the Alpha proposition.”Charles Proctor added: “I am delighted to be joining Alpha Petroleum. The team’s strong industry experience and operational knowledge put the firm in a commanding position to take advantage of an opportunity such as Cheviot, which is already making swift and impressive progress.”The appointment of a CFO comes as Alpha Petroleum continues to make progress with plans to develop Cheviot oil field, one of the largest undeveloped fields in the UK North Sea.The company recently announced that GE Oil & Gas would partner with the firm on the advancement of the subsea infrastructure for Cheviot. In April, Alpha Petroleum announced it had entered into a Front-End Engineering and Design study agreement with Teekay Offshore Partners for its Varg floating production storage and offloading (FPSO) unit.Alpha expects to achieve sanction for the Cheviot development during the fourth quarter of 2017 and is targeting first oil production in 2019, at an expected rate of at least 30,000 barrels per day.
32 Views one comment Tweet Share Sharing is caring! LocalNews Trial into death of Portsmouth man begins by: – July 2, 2012 Share Share A trial to determine whether Stebin Valentine did unlawfully cause the death of a Portsmouth man, entered day one at the High Court on Monday.Valentine is charged with manslaughter of Charlesworth Christopher Junior, which occurred on 30th August, 2009.Christopher was allegedly at his home on that evening, sitting on his steps when Valentine came to him and attempted to show him a pistol.That pistol reportedly “accidentally” went off, causing Christopher’s death.A nine member jury has selected; five men and four women, and the first witness is expected to take the witness stand later this morning.Meanwhile, the trial to determine whether Jackie Languedoc did unlawfully kiled Gerald Dover Junior has been traversed again.In January, 2012 the trial was traversed to the May 2012 Criminal Assizes after notices of discontinuance had been filed against Kironie Sandy, Chris Thomas and Sammie Harve who were jointly charged with Languedoc.On Monday, the Director of Public Prosecution, Gene Pestaina, requested an adjournment as the state’s star witness, a police officer, was out of state and is scheduled to return at the end of the month.Justice Birnie Stephenson-Brooks traversed the matter to the September 2012 Criminal Assizes, as the May 2012 Criminal Assizes is scheduled to climax at the end of July.She ordered that this trial be given “high priority” in the September Assizes.Justice Brooks also warned Languedoc who is currently on bail to “continue to be of good behavior and to lead an honest and industrious life”.Dominica Vibes News
UWF Women’s Soccer Sweeps Gulf South Conference Weekly Awards Nov. 1, 2007BIRMINGHAM, Ala. – Dernelle Mascall and Sheka Codner were named the GSC Offensive and Defensive players of the week this past week. They become the sixth and seventh different Argos to earn player of the week honors this season for women’s soccer. Previously, Brandi Adams (Sr. / Gulf Breeze, Fla.) and Jodi Galucci (So. / Stuart, Fla.) were honored as offensive players of the week, while Marie Hastings (Sr. / Gainesville, Fla.) and Linda Ganehed (Fr. / Sweden) each won a defensive player of the week honor. In addition, goalkeeper Courtney Jones (So. / Panama City, Fla.) has won defender of the week two separate times this season.Forward Dernelle Mascall (Basse terre, Moruga, Trinidad) earned her first career GSC Player of the Week award after recording her third hat-trick of the season this past weekend. Mascall broke West Florida’s single-season goal record (22) with four in two matches while adding two assists. She was a part of every Argo goal in the two contests. The 5-8 swift footed Sophomore netted all three goals against Montevallo Friday night, clinching the top spot for UWF in the upcoming GSC Tournament, 3-0. In Sunday’s match with Thomas (Ga.), Mascall netted a goal and assisted on two more as UWF closed out the regular season with a 3-0 win.Defender Sheka Codner (Dover, Del.) claimed her first GSC Defender of the Week honor after playing all 180 minutes for West Florida over the weekend, as the Argos blanked two opponents by a pair of 3-0 scores. The 5-5 Junior anchored a defense that allowed Montevallo just two shots on goal and held Thomas (Ga.) to only one total shot. The 3-0 victory over the Lady Falcons clinched the top seed in the GSC Tournament for UWF. Amazingly, Codner and her defensive companions have not allowed a goal in the last 790 minutes of play. Print Friendly Version Share
Pearson recalls the pressure on boss Robson during the survival battle and admitted it was difficult to watch. “I remember when we played Manchester United in the penultimate game of the season,” he said. “The early results had put us under pressure, we needed something at Manchester United. We got a 1-1 draw. It was a tough day but we managed to get into the last day with a mathematical chance. “Those sort of pressures, when you watch someone you know well having to endure them, it’s quite hard, it’s tough. “Bryan was the manager, he takes more pressure than the assistant. It was interesting for me to see it from a different perspective. “It will be interesting for me to observe myself I’m sure. I’m not sure what I’d make of myself. “You need balance and as a manager you need somebody who at least has an understanding of the personality. I’m very lucky to have members of staff who manage to manage me.” Pearson will be without attacking midfielder Matty James, who could be out until next year after suffering cruciate knee ligament damage. Striker David Nugent (calf) is also sidelined but midfielder Andy King will return to the squad following a hamstring injury. The Foxes will survive at Sunderland on Saturday and complete a remarkable survival mission if Hull fail to match their result at Tottenham. Friday marked 10 years since Pearson was involved in the first Houdini act when West Brom became the first team to beat the drop in the Premier League after being bottom at Christmas. Press Association He was assistant to Bryan Robson at The Hawthorns as the Baggies survived on the final day with a 2-0 win over Portsmouth. Sunderland themselves achieved it last season and with Leicester on the brink of repeating it Pearson wants to seal survival without any late slip-ups. “It’s the worst pressure ever when you need to win games and also hoping things go your way elsewhere,” he said. “That is not nice. So one of the things we have been working very hard to do is hoping it stays in our own hands. “To do that you have to get enough good results but we have managed to do that. We will be doing everything we can to make sure it’s the right result for ourselves.” The Foxes have won six of their last seven games in a stunning run of form to climb off the bottom of the table and rise to 15th. They are three points above third-bottom Hull with a better goal difference and are set to emulate West Brom’s achievement. The Baggies stayed up on ‘Survival Sunday’, sending Southampton, Norwich and Crystal Palace down despite starting the day bottom. Nigel Pearson wants to avoid the “worst pressure ever” as Leicester close in on their own Great Escape.